Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

Despite extensive study, the role of phosphatidylinositol 3-kinase (PI3-kinase) activation in CD28 function has been highly contentious. To definitively address this question, we generated knock-in mice expressing mutations in two critical domains of the cytoplasmic tail of CD28. Mutation of the pro...

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Autores principales: Dodson, Lindzy F., Boomer, Jonathan S., Deppong, Christine M., Shah, Dulari D., Sim, Julia, Bricker, Traci L., Russell, John H., Green, Jonathan M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698768/
https://ncbi.nlm.nih.gov/pubmed/19398586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01869-08
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