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5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease
5-Lipoxygenase (5LO), by producing leukotrienes, is a proinflammatory enzyme, and there is evidence suggesting that it is up-regulated with aging and may be involved in Alzheimer’s disease (AD). In this paper, we studied the effect of 5LO-targeted gene disruption on the amyloid phenotype of a transg...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698428/ https://ncbi.nlm.nih.gov/pubmed/17998412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-9131.com |
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