A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen

BACKGROUND: Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug resistant when it encounters multiple stresses within the host. Inability of currently available drugs to kill latent Mtb is a major impediment to curing and possibly eradicating tuberculosis (TB). Most in vitro dor...

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Detalhes bibliográficos
Main Authors: Deb, Chirajyoti, Lee, Chang-Muk, Dubey, Vinod S., Daniel, Jaiyanth, Abomoelak, Bassam, Sirakova, Tatiana D., Pawar, Santosh, Rogers, Linda, Kolattukudy, Pappachan E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698117/
https://ncbi.nlm.nih.gov/pubmed/19562030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006077
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