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Downregulation of Wnt signaling is an early signal for formation of facultative heterochromatin and onset of cell senescence in primary human cells
Cellular senescence is an irreversible proliferation arrest of primary cells and an important tumor suppression process. Senescence is often characterized by domains of facultative heterochromatin, called Senescence-Associated Heterochromatin Foci (SAHF), which repress expression of proliferation-pr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698096/ https://ncbi.nlm.nih.gov/pubmed/17643369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.05.034 |
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