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Asimadoline, a κ-Opioid Agonist, and Visceral Sensation
Asimadoline is a potent κ-opioid receptor agonist with a diaryl acetamide structure. It has high affinity for the κ receptor, with IC(50) of 5.6 nM (guinea pig) and 1.2 nM (human recombinant), and high selectively with κ: μ: δ binding ratios of 1:501:498 in human recombinant receptors. It acts as a...
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698012/ https://ncbi.nlm.nih.gov/pubmed/18715494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2982.2008.01183.x |
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