Etanercept prevents airway hyperresponsiveness by protecting neuronal M(2) muscarinic receptors in antigen-challenged guinea pigs

Eitemau Tebyg

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• Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M(2) muscarinic receptor dysfunction
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• Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways.
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• Effects of tachykinin NK(1) receptor antagonists on vagal hyperreactivity and neuronal M(2) muscarinic receptor function in antigen challenged guinea-pigs
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• Function of pulmonary M2 muscarinic receptors in antigen-challenged guinea pigs is restored by heparin and poly-L-glutamate.
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