Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury

BACKGROUND AND PURPOSE: The effects of a phosphodiesterase 4 (PDE4) inhibitor, roflumilast, on bleomycin-induced lung injury were explored in ‘preventive’ and ‘therapeutic’ protocols and compared with glucocorticoids. EXPERIMENTAL APPROACH: Roflumilast (1 and 5 mg·kg(−1)·d(−1), p.o.) or dexamethason...

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Bibliografiset tiedot
Päätekijät: Cortijo, J, Iranzo, A, Milara, X, Mata, M, Cerdá-Nicolás, M, Ruiz-Saurí, A, Tenor, H, Hatzelmann, A, Morcillo, EJ
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Publishing Ltd 2009
Aiheet:
Research Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697678/
https://ncbi.nlm.nih.gov/pubmed/19154443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00041.x
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