Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability

BACKGROUND AND PURPOSE: The present study addressed the effects of the investigational PDE4 inhibitor roflumilast on leukocyte-endothelial cell interactions and endothelial permeability in vivo and in vitro. EXPERIMENTAL APPROACH: In vivo, intravital video-microscopy was used to determine effects of...

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Detalhes bibliográficos
Main Authors: Sanz, M-J, Cortijo, J, Taha, M A, Cerdá-Nicolás, M, Schatton, E, Burgbacher, B, Klar, J, Tenor, H, Schudt, C, Issekutz, A C, Hatzelmann, A, Morcillo, E J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2050829/
https://ncbi.nlm.nih.gov/pubmed/17704822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707428
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