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Structure of the Inhibitor W7 Bound to the Regulatory Domain of Cardiac Troponin C

[Image: see text] The calmodulin antagonist W7 binds to troponin C in the presence of Ca(2+) and inhibits striated muscle contraction. This study integrates multiple data into the structure of the regulatory domain of human cardiac troponin C (cNTnC) bound to Ca(2+) and W7. The protein−W7 interface...

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Autors principals: Hoffman, Ryan M. B., Sykes, Brian D.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2009
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697600/
https://ncbi.nlm.nih.gov/pubmed/19419198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9001826
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