Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59

The unique species specificity of the bacterial cytolysin intermedilysin is explained by its requirement for the human complement regulator CD59 as the primary receptor. Binding studies using individual domains of intermedilysin mapped the CD59-binding site to domain 4 and swap mutants between human...

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Hlavní autoři: Hughes, Timothy R., Ross, Kirsty S., Cowan, Graeme J.M., Sivasankar, Baalasubramanian, Harris, Claire L., Mitchell, Timothy J., Morgan, B. Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Pergamon Press 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697320/
https://ncbi.nlm.nih.gov/pubmed/19200600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.01.003
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