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Wnt5a Induces Simultaneous Cortical Axon Outgrowth and Repulsive Axon Guidance through Distinct Signaling Mechanisms

Wnts are morphogens that also function as axon guidance molecules. In vivo Wnt5a gradients via Ryk receptors were found to repel cortical axons into developing callosal and corticospinal pathways. Here, using dissociated cortical cultures, we found that bath-applied Wnt5a increased axon outgrowth. I...

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Autori principali: Li, Li, Hutchins, B. Ian, Kalil, Katherine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697037/
https://ncbi.nlm.nih.gov/pubmed/19420254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0183-09.2009
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