Wird geladen...

p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

The 66 KDa isoform of Shc and its signalling properties have attracted in the past years major interest in aging research. Here, we summarize p66Shc functions and outline a specific signalling route leading to mitochondrial import, that accounts for its pro-apoptotic activity upon oxidative stress....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pinton, Paolo, Rizzuto, Rosario
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696632/
https://ncbi.nlm.nih.gov/pubmed/18235239
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!