GlcNAc6ST-1-Mediated Decoration of MAdCAM-1 Protein with L-Selectin Ligand Carbohydrates Directs Disease Activity of Ulcerative Colitis

BACKGROUND: A diffuse lymphocyte infiltrate is one of the characteristic features of ulcerative colitis (UC). Such lymphocyte recruitment requires lymphocyte rolling mediated by L-selectin ligand carbohydrates (6-sulfo sialyl Lewis X-capped O-glycans) and/or mucosal addressin cell adhesion molecule...

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Main Authors: Kobayashi, Motohiro, Hoshino, Hitomi, Masumoto, Junya, Fukushima, Mana, Suzawa, Kenichi, Kageyama, Shunsuke, Suzuki, Manabu, Ohtani, Haruo, Fukuda, Minoru, Nakayama, Jun
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696616/
https://ncbi.nlm.nih.gov/pubmed/19067429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.20827
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