Resveratrol Inhibits Dioxin-Induced Expression of Human CYP1A1 and CYP1B1 by Inhibiting Recruitment of the Aryl Hydrocarbon Receptor Complex and RNA Polymerase II to the Regulatory Regions of the Corresponding Genes

The CYP1A family of cytochrome P450s (CYPs), comprising CYP1A1, CYP1A2, and CYP1B1, plays a role in bioactivation of several procarcinogens to carcinogenic derivatives, and also in detoxification of several xenobiotic compounds. Resveratrol (3,4,5-trihydroxystelbine) is a naturally occurring compoun...

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Bibliographic Details
Main Authors: Beedanagari, Sudheer R., Bebenek, Ilona, Bui, Peter, Hankinson, Oliver
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Carcinogenicity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696325/
https://ncbi.nlm.nih.gov/pubmed/19376845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp079
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