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Regulation of XIAP translation and induction by MDM2 following irradiation
Increases in protein levels of XIAP in cancer cells have been associated with resistance to apoptosis induced by cellular stress. Herein we demonstrate that the upregulation of XIAP protein levels is regulated by MDM2 at the translational level. MDM2 was found to physically interact with the IRES of...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2696306/ https://ncbi.nlm.nih.gov/pubmed/19411066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.03.002 |
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