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Discovery of dual inhibitors of MDM2 and XIAP for cancer treatment
MDM2 and XIAP are mutually regulated: Binding of MDM2 RING protein to the IRES region on XIAP mRNA results in MDM2 protein stabilization and enhanced XIAP translation. In this study, we developed a protein-RNA fluorescence polarization (FP) assay for high-throughput screening (HTS) of chemical libra...
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| Publicado no: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5079537/ https://ncbi.nlm.nih.gov/pubmed/27666947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.08.015 |
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