Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines

Dysregulation of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of alcoholic liver injury. Sirtuin 1 (SIRT1) is an NAD(+)-dependent class III protein deacetylase that is known to be involved in regulating production of proinflammatory cytoki...

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Main Authors: Shen, Zheng, Ajmo, Joanne M., Rogers, Christopher Q., Liang, Xiaomei, Le, Lisa, Murr, Michel M., Peng, Yanhua, You, Min
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2009
Assuntos:
Inflammation/Immunity/Mediators
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696216/
https://ncbi.nlm.nih.gov/pubmed/19299582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00016.2009
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