Inflammation-induced, 3′UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis

Although the inducible heat shock protein 70 (Hsp70) is essential for maintaining intestinal homeostasis in colitis, it is translationally downregulated in inflamed colonic mucosa, paradoxically rendering the gut more susceptible to injury. We examined the basis for this process by analyzing the rol...

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Autores principales: Hu, Shien, Zhu, Xiaorong, Triggs, Joseph R., Tao, Yun, Wang, Yunwei, Lichtenstein, Lev, Bissonnette, Marc, Musch, Mark W., Chang, Eugene B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2009
Materias:
Inflammation/Immunity/Mediators
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696214/
https://ncbi.nlm.nih.gov/pubmed/19299581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00027.2009
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