Inflammation-induced, 3′UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis

Although the inducible heat shock protein 70 (Hsp70) is essential for maintaining intestinal homeostasis in colitis, it is translationally downregulated in inflamed colonic mucosa, paradoxically rendering the gut more susceptible to injury. We examined the basis for this process by analyzing the rol...

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Détails bibliographiques
Auteurs principaux: Hu, Shien, Zhu, Xiaorong, Triggs, Joseph R., Tao, Yun, Wang, Yunwei, Lichtenstein, Lev, Bissonnette, Marc, Musch, Mark W., Chang, Eugene B.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2009
Sujets:
Inflammation/Immunity/Mediators
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696214/
https://ncbi.nlm.nih.gov/pubmed/19299581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00027.2009
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