Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene

Congenic DRF.(f/f) rats are protected from type 1 diabetes (T1D) by 34 Mb of F344 DNA introgressed proximal to the gimap5 lymphopenia gene. To dissect the genetic factor(s) that confer protection from T1D in the DRF.(f/f) rat line, DRF.(f/f) rats were crossed to inbred BBDR or DR.(lyp/lyp) rats to g...

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Autores principales: Fuller, J. M., Bogdani, M., Tupling, T. D., Jensen, R. A., Pefley, R., Manavi, S., Cort, L., Blankenhorn, E. P., Mordes, J. P., Lernmark, Å., Kwitek, A. E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696149/
https://ncbi.nlm.nih.gov/pubmed/19351909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00015.2009
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