A unique role for autophagy and Atg16L1 in Paneth cells in murine and human intestine

Susceptibility to Crohn's disease (CD), a complex inflammatory disease involving the small intestine, is controlled by up to 32 loci1. One CD risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG162. It is not known how Atg16L1 or autophagy contributes to intest...

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Hauptverfasser: Cadwell, Ken, Liu, John, Brown, Sarah L., Miyoshi, Hiroyuki, Loh, Joy, Lennerz, Jochen, Kishi, Chieko, KC, Wumesh, Carrero, Javier A., Hunt, Steven, Stone, Christian, Brunt, Elizabeth M., Xavier, Ramnik J., Sleckman, Barry P., Li, Ellen, Mizushima, Noboru, Stappenbeck, Thaddeus S., Virgin, Herbert W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695978/
https://ncbi.nlm.nih.gov/pubmed/18849966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07416
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