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P-glycoprotein-mediated resistance to HSP90-directed therapy is eclipsed by the heat shock response

Despite studies that demonstrate the antitumor activity of Hsp90 inhibitors such as geldanamycin (GA) and its derivative 17-allylamino-demethoxygeldanamycin (17-AAG), recent reports indicate that these inhibitors lack significant single-agent clinical activity. Resistance to Hsp90 inhibitors has bee...

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Detalhes bibliográficos
Main Authors: McCollum, Andrea K., TenEyck, Cynthia J., Stensgard, Bridget, Morlan, Bruce W., Ballman, Karla V., Jenkins, Robert B., Toft, David O., Erlichman, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695926/
https://ncbi.nlm.nih.gov/pubmed/18794130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-5175
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