Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis(1)

At the majority of mutants in the region Glu181-Val200 incorporating a conserved AsnPheThrΦΦxLys motif cysteine substitution had no effect on sensitivity to ATP, partial agonists, or methanethiosulfonate (MTS) compounds. For the F185C mutant the efficacy of partial agonists was reduced by ∼ 90% but...

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Main Authors: Roberts, Jonathan A, Valente, Marie, Allsopp, Rebecca C, Watt, David, Evans, Richard J
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Ltd 2009
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695859/
https://ncbi.nlm.nih.gov/pubmed/19519776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.06035.x
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