Tumor-Targeted HPMA Copolymer-(RGDfK)-(CHX-A″-DTPA) Conjugates Show Increased Kidney Accumulation

N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-RGDfK conjugates targeting the α(v)β(3) integrin have shown increased accumulation in solid tumors and promise for selective delivery of radiotherapeutics to sites of angiogenesis- or tumor-expressed α(v)β(3) integrin. An unresolved issue in target...

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Autors principals: Borgman, Mark P., Coleman, Tomika, Kolhatkar, Rohit B., Geyser-Stoops, Sandra, Line, Bruce R., Ghandehari, Hamidreza
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695845/
https://ncbi.nlm.nih.gov/pubmed/18687371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.07.014
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