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New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer

DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders. The first histone deacetylase inhibitor, vorinostat, has been lice...

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Bibliografiske detaljer
Main Authors: Cang, Shundong, Ma, Yuehua, Liu, Delong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695818/
https://ncbi.nlm.nih.gov/pubmed/19486511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-2-22
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