iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice

Leishmania major parasites reside and multiply in late endosomal compartments of host phagocytic cells. Immune control of Leishmania growth absolutely requires expression of inducible Nitric Oxide Synthase (iNOS/NOS2) and subsequent production of NO. Here, we show that CD11b(+) CD11c(+) Ly-6C(+) MHC...

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Main Authors: De Trez, Carl, Magez, Stefan, Akira, Shizuo, Ryffel, Bernhard, Carlier, Yves, Muraille, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695779/
https://ncbi.nlm.nih.gov/pubmed/19557162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000494
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