NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist circumference (WC). In total, three loci reached genome-wide significance. In stag...

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Detalhes bibliográficos
Main Authors: Heard-Costa, Nancy L., Zillikens, M. Carola, Monda, Keri L., Johansson, Åsa, Harris, Tamara B., Fu, Mao, Haritunians, Talin, Feitosa, Mary F., Aspelund, Thor, Eiriksdottir, Gudny, Garcia, Melissa, Launer, Lenore J., Smith, Albert V., Mitchell, Braxton D., McArdle, Patrick F., Shuldiner, Alan R., Bielinski, Suzette J., Boerwinkle, Eric, Brancati, Fred, Demerath, Ellen W., Pankow, James S., Arnold, Alice M., Chen, Yii-Der Ida, Glazer, Nicole L., McKnight, Barbara, Psaty, Bruce M., Rotter, Jerome I., Amin, Najaf, Campbell, Harry, Gyllensten, Ulf, Pattaro, Cristian, Pramstaller, Peter P., Rudan, Igor, Struchalin, Maksim, Vitart, Veronique, Gao, Xiaoyi, Kraja, Aldi, Province, Michael A., Zhang, Qunyuan, Atwood, Larry D., Dupuis, Josée, Hirschhorn, Joel N., Jaquish, Cashell E., O'Donnell, Christopher J., Vasan, Ramachandran S., White, Charles C., Aulchenko, Yurii S., Estrada, Karol, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, André G., Witteman, Jacqueline C. M., Oostra, Ben A., Kaplan, Robert C., Gudnason, Vilmundur, O'Connell, Jeffrey R., Borecki, Ingrid B., van Duijn, Cornelia M., Cupples, L. Adrienne, Fox, Caroline S., North, Kari E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695005/
https://ncbi.nlm.nih.gov/pubmed/19557197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000539
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