X Chromosome Inactivation Is Initiated in Human Preimplantation Embryos

X chromosome inactivation (XCI) is the mammalian mechanism that compensates for the difference in gene dosage between XX females and XY males. Genetic and epigenetic regulatory mechanisms induce transcriptional silencing of one X chromosome in female cells. In mouse embryos, XCI is initiated at the...

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Detalhes bibliográficos
Main Authors: van den Berg, Ilse M., Laven, Joop S.E., Stevens, Mary, Jonkers, Iris, Galjaard, Robert-Jan, Gribnau, Joost, Hikke van Doorninck, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694969/
https://ncbi.nlm.nih.gov/pubmed/19481196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2009.05.003
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