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TGF-β has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines

TGF-β is a pluripotent cytokine that can have both tumor suppressing and tumor promoting effects on epithelial cells. It is unclear what determines when TGF-β and its signaling pathway act predominantly as a tumor suppressor pathway or as a tumor-promoter pathway and whether TGF-β can have both clas...

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Detalhes bibliográficos
Main Authors: MUÑOZ, NINA M., BAEK, JI YEON, GRADY, WILLIAM M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694855/
https://ncbi.nlm.nih.gov/pubmed/18651288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/08977190802291667
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