Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences

BACKGROUND: Thymidylate synthase (TS) is known to have a unique 28 bp tandemly repeated sequence in the promoter region, and the majorities of subjects have a heterozygous double repeat/triple repeat genotype in their non-cancerous tissue. Loss of heterozygosity (LOH) at the TS locus is known to occ...

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Main Authors: Kuramochi, Hidekazu, Uchida, Kazumi, Peters, Jeffery H, Shimizu, Daisuke, Vallbohmer, Daniel, Schneider, Sylke, Danenberg, Kathleen D, Danenberg, Peter V
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694818/
https://ncbi.nlm.nih.gov/pubmed/19460136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-157
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