Gene Specificity of Suppression of Transgene-Mediated Insertional Transcriptional Activation by the Chicken HS4 Insulator

Insertional mutagenesis has emerged as a major obstacle for gene therapy based on vectors that integrate randomly in the genome. Reducing the genotoxicity of genomic viral integration can, in first approximation, be equated with reducing the risk of oncogene activation, at least in the case of thera...

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Bibliographic Details
Main Authors: Desprat, Romain, Bouhassira, Eric E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694267/
https://ncbi.nlm.nih.gov/pubmed/19536296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005956
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