Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra(®), TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

BACKGROUND: Ezatiostat hydrochloride liposomes for injection, a glutathione S-transferase P1-1 inhibitor, was evaluated in myelodysplastic syndrome (MDS). The objectives were to determine the safety, pharmacokinetics, and hematologic improvement (HI) rate. Phase 1-2a testing of ezatiostat for the tr...

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Detalhes bibliográficos
Main Authors: Raza, Azra, Galili, Naomi, Callander, Natalie, Ochoa, Leonel, Piro, Lawrence, Emanuel, Peter, Williams, Stephanie, Burris, Howard, Faderl, Stefan, Estrov, Zeev, Curtin, Peter, Larson, Richard A, Keck, James G, Jones, Marsha, Meng, Lisa, Brown, Gail L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694211/
https://ncbi.nlm.nih.gov/pubmed/19439093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-2-20
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