Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53

The p53 tumor suppressor gene can inhibit proliferation transiently, induce permanent cell-cycle arrest/senescence, or cause apoptosis depending on the cellular context. The mitogen-activated protein kinase (MAPK) cascade is known to play a crucial role in cell proliferation and differentiation. Mor...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lee, Sam W., Fang, Li, Igarashi, Makoto, Ouchi, Toru, Lu, Kun Ping, Aaronson, Stuart A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26942/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890907/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.150024397
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