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Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53

The p53 tumor suppressor gene can inhibit proliferation transiently, induce permanent cell-cycle arrest/senescence, or cause apoptosis depending on the cellular context. The mitogen-activated protein kinase (MAPK) cascade is known to play a crucial role in cell proliferation and differentiation. Mor...

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Bibliografiske detaljer
Main Authors: Lee, Sam W., Fang, Li, Igarashi, Makoto, Ouchi, Toru, Lu, Kun Ping, Aaronson, Stuart A.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC26942/
https://ncbi.nlm.nih.gov/pubmed/10890907
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