A superior drug carrier – aponeocarzinostatin in partially unfolded state fully protects the labile antitumor enediyne

BACKGROUND: Neocarzinostatin is a potent antitumor drug consisting of an enediyne chromophore and a protein carrier. METHODS: We characterized an intermediate in the equilibrium unfolding pathway of aponeocarzinostatin, using a variety of biophysical techniques including 1-anilino-8-napthalene sulfo...

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Detalhes bibliográficos
Main Authors: Shanmuganathan, Aranganathan, Kumar, Thallapuranam Krishnaswamy Suresh, Huang, Chiy-Mey, Yu, Chin, Chin, Der-Hang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694159/
https://ncbi.nlm.nih.gov/pubmed/19463188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-16-48
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