Attenuated AMPA Receptor Expression Allows Glioblastoma Cell Survival in Glutamate-Rich Environment

BACKGROUND: Glioblastoma multiforme (GBM) cells secrete large amounts of glutamate that can trigger AMPA-type glutamate receptors (AMPARs). This commonly results in Na(+) and Ca(2+)-permeability and thereby in excitotoxic cell death of the surrounding neurons. Here we investigated how the GBM cells...

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Detalhes bibliográficos
Main Authors: van Vuurden, Dannis G., Yazdani, Maryam, Bosma, Ingeborg, Broekhuizen, Aart J. F., Postma, Tjeerd J., Heimans, Jan J., van der Valk, Paul, Aronica, Eleonora, Tannous, Bakhos A., Würdinger, Thomas, Kaspers, Gertjan J. L., Cloos, Jacqueline
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693929/
https://ncbi.nlm.nih.gov/pubmed/19536293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005953
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