MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

AIM: To investigate the anti-neoplastic effect of MK615, an anti-neoplastic compound isolated from Japanese apricot, against human pancreatic cancer cells in vitro. METHODS: Three human pancreatic cancer cell lines PANC-1, PK-1, and PK45H were cultured with MK615 at concentrations of 600, 300, 150,...

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Hlavní autoři: Okada, Toshie, Sawada, Tokihiko, Osawa, Tatsushi, Adachi, Masakazu, Kubota, Keiichi
Médium: Artigo
Jazyk:Inglês
Vydáno: The WJG Press and Baishideng 2008
Témata:
Rapid Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693685/
https://ncbi.nlm.nih.gov/pubmed/18322951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.14.1378
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