Disruption of Protein Kinase A in Mice Enhances Healthy Aging

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIβ, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean and insulin sensitive. It was therefore hypothesized t...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Enns, Linda C., Morton, John F., Treuting, Piper R., Emond, Mary J., Wolf, Norman S., McKnight, G. S., Rabinovitch, Peter S., Ladiges, Warren C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693670/
https://ncbi.nlm.nih.gov/pubmed/19536287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005963
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