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Cytochrome P450 2C9 Variants Influence Response to Celecoxib for Prevention of Colorectal Adenoma
BACKGROUND & AIMS: Variants in the cytochrome P450 2C9 (CYP2C9) gene are associated with impaired metabolism of celecoxib. We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related response or toxicity in a randomized trial of celecoxib. METHODS: We identified i...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693443/ https://ncbi.nlm.nih.gov/pubmed/19233181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.02.045 |
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