Cytochrome P450 2C9 Variants Influence Response to Celecoxib for Prevention of Colorectal Adenoma

BACKGROUND & AIMS: Variants in the cytochrome P450 2C9 (CYP2C9) gene are associated with impaired metabolism of celecoxib. We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related response or toxicity in a randomized trial of celecoxib. METHODS: We identified i...

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Autors principals: Chan, Andrew T., Zauber, Ann G., Hsu, Meier, Breazna, Aurora, Hunter, David J., Rosenstein, Rebecca B., Eagle, Craig J., Hawk, Ernest T., Bertagnolli, Monica M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693443/
https://ncbi.nlm.nih.gov/pubmed/19233181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.02.045
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