Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells

Aminoflavone (5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methylchromen-4-one; AF; NSC 686288), a novel anticancer candidate agent, is undergoing clinical evaluation. AF induces DNA-protein cross-links (DPCs), γ-H2AX phosphorylation, aryl hydrocarbon receptor (AhR) signaling, apoptosis and its...

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Detalhes bibliográficos
Main Authors: McLean, Lancelot, Soto, Ubaldo, Agama, Keli, Francis, Jawad, Jimenez, Randi, Pommier, Yves, Sowers, Lawrence, Brantley, Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693190/
https://ncbi.nlm.nih.gov/pubmed/18059023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.23244
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