Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

RepB initiates plasmid rolling-circle replication by binding to a triple 11-bp direct repeat (bind locus) and cleaving the DNA at a specific distant site located in a hairpin loop within the nic locus of the origin. The structure of native full-length RepB reveals a hexameric ring molecule, where ea...

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Detalhes bibliográficos
Main Authors: Boer, D Roeland, Ruíz-Masó, José A, López-Blanco, José R, Blanco, Alexander G, Vives-Llàcer, Mireia, Chacón, Pablo, Usón, Isabel, Gomis-Rüth, F Xavier, Espinosa, Manuel, Llorca, Oscar, del Solar, Gloria, Coll, Miquel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693155/
https://ncbi.nlm.nih.gov/pubmed/19440202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.125
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