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Activation-Induced Deaminase, AID, is catalytically active as a monomer on single-stranded DNA
Hypermutation and class switch recombination of immunoglobulin genes are antigen-activated mechanisms triggered by AID, a cytidine deaminase. AID deaminates cytidine residues in the DNA of the variable and the switch regions of the immunoglobulin locus. The resulting uracil induces error-prone DNA s...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2693009/ https://ncbi.nlm.nih.gov/pubmed/17889624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.08.002 |
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