Contributions of the Carboxyl-Terminal Helical Segment to the Self-Association and Lipoprotein Preferences of Human Apolipoprotein E3 and E4 Isoforms

To understand the molecular basis for the different self-association and lipoprotein preferences of apolipoprotein (apo) E isoforms, we compared the effects of progressive truncation of the C-terminal domain in human apoE3 and apoE4 on their lipid-free structure and lipid-binding properties. A VLDL/...

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Main Authors: Sakamoto, Takaaki, Tanaka, Masafumi, Vedhachalam, Charulatha, Nickel, Margaret, Nguyen, David, Dhanasekaran, Padmaja, Phillips, Michael C., Lund-Katz, Sissel, Saito, Hiroyuki
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692928/
https://ncbi.nlm.nih.gov/pubmed/18201068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701923h
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