B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity

32-amino acid B-type natriuretic peptide (BNP 1-32) plays an important role in cardiovascular homeostasis. Recently, it was reported that BNP 1-32 is cleaved by the metalloprotease meprin A to BNP 8-32, the bioactivity of which is undefined. We hypothesized that BNP 8-32 has reduced vasodilating and...

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Detalhes bibliográficos
Main Authors: Boerrigter, Guido, Costello-Boerrigter, Lisa C., Harty, Gail J., Huntley, Brenda K., Cataliotti, Alessandro, Lapp, Harald, Burnett, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Hemodynamics and Cardiorenal Integration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692783/
https://ncbi.nlm.nih.gov/pubmed/19386989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00059.2009
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