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Aberrant Nuclear Accumulation of Glycogen Synthase Kinase-3β in Human Pancreatic Cancer: Association with Kinase Activity and Tumor Dedifferentiation

PURPOSE: We have shown recently that glycogen synthase kinase-3 (GSK-3) β regulates nuclear factor-κB (NF-κB) – mediated pancreatic cancer cell survival and proliferation in vitro. Our objective was to determine the localization of GSK-3β in pancreatic cancer cells and assess the antitumor effect of...

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Bibliografski detalji
Glavni autori: Ougolkov, Andrei V., Fernandez-Zapico, Martin E., Bilim, Vladimir N., Smyrk, Thomas C., Chari, Suresh T., Billadeau, Daniel D.
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692690/
https://ncbi.nlm.nih.gov/pubmed/16951223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-06-0196
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