The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing

Recent results in animal models suggest that thrombin may modulate brain injury in Parkinson's disease (PD). High doses of thrombin (∼20 U) can damage dopaminergic neurons, while we have found that low dose thrombin (1 U), given several days before a brain insult (thrombin preconditioning), is...

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Bibliografiske detaljer
Main Authors: Cannon, Jason R., Hua, Ya, Richardson, Rudy J., Xi, Guohua, Keep, Richard F., Schallert, Timothy
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692235/
https://ncbi.nlm.nih.gov/pubmed/17629581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2007.06.004
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