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The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing
Recent results in animal models suggest that thrombin may modulate brain injury in Parkinson's disease (PD). High doses of thrombin (∼20 U) can damage dopaminergic neurons, while we have found that low dose thrombin (1 U), given several days before a brain insult (thrombin preconditioning), is...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692235/ https://ncbi.nlm.nih.gov/pubmed/17629581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2007.06.004 |
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