Rational Design of Protein-based MRI Contrast Agents

We describe the rational design of a novel class of magnetic resonance imaging contrast agents with engineered proteins (CAi.CD2, i = 1, 2, …, 9) chelated with gadolinium. The design of protein-based contrast agents involves creating high coordination Gd(3+) binding sites in a stable host protein us...

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Detalhes bibliográficos
Principais autores: Yang, Jenny J., Yang, Jianhua, Wei, Lixia, Zurkiya, Omar, Yang, Wei, Li, Shunyi, Zou, Jin, Zhou, Yubin, Maniccia, Anna L Wilkins, Mao, Hui, Zhao, Fuqiang, Malchow, Russell, Zhao, Shumin, Johnson, Julian, Hu, Xiaoping, Krogstad, Eirik, Liu, Zhi-Ren
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692035/
https://ncbi.nlm.nih.gov/pubmed/18576649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja800736h
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