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Rational design of a conformation switchable Ca(2+) and Tb(3+) binding protein without using multiple coupled metal binding sites

Ca(2+) as a messenger of signal transduction regulates numerous target molecules via Ca(2+)-induced conformational changes. Investigation into the determinants for Ca(2+)-induced conformational change is often impeded by cooperativity between multiple metal binding sites or protein oligomerization i...

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Main Authors: Li, Shunyi, Yang, Wei, Maniccia, Anna Wilkins, Barrow, Doyle, Tjong, Harianto, Zhou, Huan-Xiang, Yang, Jenny J
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613763/
https://ncbi.nlm.nih.gov/pubmed/18785925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06638.x
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