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Rational design of a conformation switchable Ca(2+) and Tb(3+) binding protein without using multiple coupled metal binding sites
Ca(2+) as a messenger of signal transduction regulates numerous target molecules via Ca(2+)-induced conformational changes. Investigation into the determinants for Ca(2+)-induced conformational change is often impeded by cooperativity between multiple metal binding sites or protein oligomerization i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613763/ https://ncbi.nlm.nih.gov/pubmed/18785925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06638.x |
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