Rational design of a conformation switchable Ca(2+) and Tb(3+) binding protein without using multiple coupled metal binding sites

Ca(2+) as a messenger of signal transduction regulates numerous target molecules via Ca(2+)-induced conformational changes. Investigation into the determinants for Ca(2+)-induced conformational change is often impeded by cooperativity between multiple metal binding sites or protein oligomerization i...

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Bibliographic Details
Main Authors:	Li, Shunyi, Yang, Wei, Maniccia, Anna Wilkins, Barrow, Doyle, Tjong, Harianto, Zhou, Huan-Xiang, Yang, Jenny J
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2613763/ https://ncbi.nlm.nih.gov/pubmed/18785925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06638.x
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Rational design of a conformation switchable Ca(2+) and Tb(3+) binding protein without using multiple coupled metal binding sites

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