Modulation of Gene Expression by Human Cytosolic tRNase Z(L) through 5′-Half-tRNA

A long form (tRNase Z(L)) of tRNA 3′ processing endoribonuclease (tRNase Z, or 3′ tRNase) can cleave any target RNA at any desired site under the direction of artificial small guide RNA (sgRNA) that mimics a 5′-half portion of tRNA. Based on this enzymatic property, a gene silencing technology has b...

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Detalhes bibliográficos
Main Authors: Elbarbary, Reyad A., Takaku, Hiroaki, Uchiumi, Naoto, Tamiya, Hiroko, Abe, Mayumi, Takahashi, Masayuki, Nishida, Hiroshi, Nashimoto, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691602/
https://ncbi.nlm.nih.gov/pubmed/19526060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005908
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