Identification by Mn(2+) rescue of two residues essential for the proton transfer of tRNase Z catalysis

Thermotoga maritima tRNase Z cleaves pre-tRNAs containing the (74)CCA(76) sequence precisely after the A(76) residue to create the mature 3′ termini. Its crystal structure has revealed a four-layer αβ/βα sandwich fold that is typically found in the metallo-β-lactamase superfamily. The well-conserved...

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Autores principales: Minagawa, Asako, Takaku, Hiroaki, Ishii, Ryohei, Takagi, Masamichi, Yokoyama, Shigeyuki, Nashimoto, Masayuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1540738/
https://ncbi.nlm.nih.gov/pubmed/16916792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl517
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